Hyaluronidase Injection

Thinking of getting your dermal fillers removed? Learn how hyaluronidase dissolves dermal fillers

Hyaluronidase Aesthetic Injection Lips

The huge rise in the number of women and men of all backgrounds and ages seeking dermal filler treatment has sparked a new trend: dermal filler reversal.

Celebrities and social media influencers are joining the bandwagon in what the media is dubbing as the ‘explant movement’ or the ‘lip switch’, but what does the procedure actually involve?

While it is possible to get your dermal fillers removed, you should fully understand what this procedure entails and know that it’s a decision that shouldn’t be taken lightly.

What is hyaluronidase and how can it remove dermal fillers?

Firstly, it’s important to note that it’s much easier to remove dermal fillers made from hyaluronic acid than from other substances. Removal of non-hyaluronic acid dermal fillers will require surgical interventions, while hyaluronic acid dermal fillers can be safely removed using hyaluronidase.

Hyaluronidase is an enzyme that can be injected into the skin to remove or ‘dissolve’ dermal filler. It does this by degrading and breaking down the hyaluronic acid.

The results are immediate; however it can take days for final results to be seen and treatments may need to be repeated.

Why remove dermal fillers with hyaluronidase?

Occasionally, people are unhappy with the results of their dermal fillers. If you have hyaluronic acid dermal fillers you can wait for your body’s natural hyaluronidase to remove the filler over time, or you can speak to your practitioner about removing them for you.

Other reasons why people might be injected with hyaluronidase is to resolve aesthetic complications, such as asymmetry, lumps and nodules, which can form following treatment. Some very rare but serious complications require immediate action, such as a vascular occlusion (when a dermal filler blocks the blood flow in your vessels) which can lead to necrosis (tissue death) or in very rare circumstances, blindness.

Your medical practitioner is the best person to speak to if you are thinking about getting your dermal fillers removed, or if you think you are experiencing any complications after your treatment.

Can you get dermal fillers again after removing them with hyaluronidase? 


You can be reinjected with dermal filler after you have had the removed! However, you will not be able to do this straight away.

To let your skin settle after the hyaluronidase injections, your practitioner will recommend you wait several weeks before they reinject you again. This will vary amongst individuals and your practitioner will know the best treatment plan for you.

What are the risks of hyaluronidase injections?

No medical aesthetic treatment comes without a risk, however small, and hyaluronidase is no different.

The common injection-related reactions that might occur include redness, swelling, pain, itching, bruising and tenderness at the injection site. As hyaluronidase is an enzyme that breaks down hyaluronic acid, there is a risk that it can also break down naturally-occurring hyaluronic acid present in your body.

This can potentially impact the quality of the skin in the area, which might not produce a good aesthetic result. Administration of hyaluronidase can also result in anaphylaxis (severe allergic reaction). A medical practitioner should conduct a thorough consultation to ensure you are suitable for treatment.

It should be noted that hyaluronidase is not a ‘miracle cure’ and just because you have this reversal, it doesn’t mean that you will be fully satisfied with your results.

Who can perform hyaluronidase injections?

Hyaluronidase is classified as a drug and is therefore a prescription-only medicine. In the UK, as aesthetics is an unregulated market, any practitioner is legally allowed to inject hyaluronidase, however the drug is only available via a prescription from a suitably-qualified medical professional with a prescribing license (such as a registered doctor, prescribing nurse, dentist or prescribing pharmacist).

Practitioners who are not prescribers are forbidden to inject hyaluronidase if their patient has not had a face-to-face consultation with a registered prescriber.

At Beyond Beauty, we only endorse medical professionals (doctors, nurses, dentists and pharmacists) who have valid insurance and are registered and regulated by the General Medical Council, Nursing and Midwifery Council, General Dental Council or the General Pharmaceutical Council to inject hyaluronidase.

To learn more about the reputable organisations in aesthetics that can help you choose a medical practitioner, click here.

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